SB-334867

SB-334,867.svg

Selective orexin receptor 1 antagonist

SB-334867
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SB-334867 is a selective orexin receptor 1 (OX1R) antagonist. It is primarily used in scientific research to study the role of orexin (also known as hypocretin) in various physiological processes, including sleep, appetite, and addiction.

Mechanism of Action

SB-334867 works by selectively blocking the orexin 1 receptor (OX1R), which is one of the two types of orexin receptors found in the body. Orexin receptors are activated by orexin A and orexin B, neuropeptides that are involved in the regulation of wakefulness and energy homeostasis. By inhibiting OX1R, SB-334867 can modulate the activity of orexin neurons, thereby affecting various physiological functions.

Research Applications

Sleep

SB-334867 has been extensively used to investigate the role of orexin in sleep regulation. Studies have shown that blocking OX1R can promote sleep and reduce wakefulness, suggesting potential therapeutic applications for insomnia and other sleep disorders.

Appetite

Research has also explored the impact of SB-334867 on appetite and food intake. Orexin is known to stimulate hunger and feeding behavior, and OX1R antagonists like SB-334867 can reduce food intake, making them potential candidates for the treatment of obesity.

Addiction

SB-334867 has been studied for its effects on addiction and substance abuse. Orexin signaling is implicated in the reward system of the brain, and blocking OX1R can reduce the reinforcing effects of addictive substances such as cocaine and alcohol.

Pharmacokinetics

The pharmacokinetic properties of SB-334867, including its bioavailability, metabolism, and elimination half-life, are subjects of ongoing research. Understanding these properties is crucial for developing potential therapeutic applications.

See Also

• Orexin receptor
• Orexin
• Sleep
• Appetite
• Addiction

References

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