S1PR5

Sphingosine-1-phosphate receptor 5 (S1PR5) is a G protein-coupled receptor that binds the bioactive lipid sphingosine-1-phosphate (S1P). This receptor is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in the regulation of various physiological processes, including immune system function and central nervous system development.

Function

S1PR5 is primarily expressed in the central nervous system, particularly in oligodendrocytes and microglia. It is involved in the regulation of neuroinflammation and myelination. The receptor mediates the effects of sphingosine-1-phosphate in promoting the survival and differentiation of oligodendrocytes, which are essential for the formation of myelin sheaths around neurons.

Clinical Significance

Alterations in S1PR5 signaling have been implicated in various neurological disorders, including multiple sclerosis and Alzheimer's disease. Therapeutic targeting of S1PR5 is being explored as a potential strategy for modulating immune responses and promoting neuroprotection in these conditions.

See Also

• Sphingosine-1-phosphate receptor
• G protein-coupled receptor
• Myelination
• Neuroinflammation

External Links

• S1PR5 Gene - NCBI
• S1PR5 Protein - UniProt