Robert Lefkowitz

Robert Lefkowitz 2 2012

Robert Lefkowitz

Robert Joseph Lefkowitz (born April 15, 1943) is an American physician and biochemist who is best known for his groundbreaking work on G protein-coupled receptors (GPCRs). He was awarded the Nobel Prize in Chemistry in 2012, along with Brian Kobilka, for their discoveries that have significantly advanced the understanding of how these receptors function.

Early Life and Education

Lefkowitz was born in New York City, New York. He attended the Bronx High School of Science and later earned his B.A. in chemistry from Columbia University in 1962. He continued his education at Columbia University College of Physicians and Surgeons, where he received his M.D. in 1966.

Career

After completing his medical degree, Lefkowitz served as a clinical and research associate at the National Institutes of Health (NIH) from 1968 to 1970. He then completed his medical residency and fellowship in cardiology at the Massachusetts General Hospital.

In 1973, Lefkowitz joined the faculty at Duke University, where he has spent the majority of his career. He is currently a James B. Duke Professor of Medicine and a Professor of Biochemistry and Chemistry at Duke University Medical Center.

Research

Lefkowitz's research has primarily focused on the molecular properties and regulatory mechanisms of GPCRs. These receptors play a crucial role in cellular communication and are the target of a large number of pharmaceutical drugs. His work has led to a deeper understanding of how these receptors function and how they can be targeted for therapeutic purposes.

One of his most significant contributions was the discovery of the beta-adrenergic receptor, a type of GPCR that responds to epinephrine and norepinephrine. This discovery has had profound implications for the treatment of various cardiovascular diseases.

Awards and Honors

Lefkowitz has received numerous awards and honors throughout his career, including:

• The Nobel Prize in Chemistry (2012)
• The National Medal of Science (2007)
• The Shaw Prize in Life Science and Medicine (2007)
• The Albany Medical Center Prize (2012)

Personal Life

Lefkowitz is married and has five children. He is also known for his mentorship and has trained many prominent scientists in the field of biochemistry and pharmacology.

See Also

• G protein-coupled receptor
• Brian Kobilka
• Nobel Prize in Chemistry
• National Institutes of Health
• Duke University