Ro60-0213
Ro60-0213 is a research chemical that belongs to the benzodiazepine class of drugs. It is known for its anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.
Chemistry
Ro60-0213 is a benzodiazepine derivative. Benzodiazepines are a class of drugs that are primarily used for treating anxiety, but they also have other uses such as treating seizures, insomnia, and alcohol withdrawal. Benzodiazepines work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties.
Pharmacology
Like other benzodiazepines, Ro60-0213 works by binding to specific sites on the GABAA receptor. This enhances the effects of GABA, a neurotransmitter that inhibits activity in the brain. The increased GABA activity results in the drug's sedative, anxiolytic, anticonvulsant, and muscle relaxant effects.
Uses
Ro60-0213, like other benzodiazepines, is primarily used in research settings. It is not currently approved for medical use in humans. However, its effects on the GABAA receptor and its anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties make it a potentially useful tool in the study of these types of drugs and the conditions they are used to treat.
Safety
As with all benzodiazepines, use of Ro60-0213 carries risks. These include dependence, withdrawal symptoms, and the potential for overdose. Because it is a research chemical, it is not intended for human consumption, and its safety profile in humans is not well-studied.
See also
- Benzodiazepine
 - Research chemical
 - [[GABAA receptor]]
 - Anxiolytic
 - Anticonvulsant
 - Hypnotic
 - Sedative
 - Skeletal muscle relaxant
 - Amnestic
 
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Contributors: Prab R. Tumpati, MD