Ribozyme

Ribozyme is a type of RNA molecule that is capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes. The term "ribozyme" was first introduced by Thomas R. Cech, who was one of the first scientists to discover the properties of these RNA molecules.

History

The discovery of ribozymes involved in peptide bond formation, RNA splicing, and RNA replication has been a significant development in the understanding of the origin of life. The concept of ribozymes was proposed by Francis Crick in 1968, but it was not until 1982 that the first ribozyme was discovered by Thomas R. Cech and his team.

Structure and Function

Ribozymes are composed of RNA and they function as part of the ribonucleoprotein particles, where they contribute to the catalytic functions that are critical for life. They are involved in a variety of cellular processes, including RNA splicing, translation, RNA processing, and gene regulation.

Types of Ribozymes

There are several types of ribozymes, including Group I introns, Group II introns, RNase P, Hammerhead ribozyme, Hairpin ribozyme, VS ribozyme, Leadzyme, Dimerization ribozyme, and Hepatitis Delta Virus (HDV) ribozyme. Each of these ribozymes has a unique structure and function.

Applications

Ribozymes have been used in various applications in biotechnology and medicine. They have been used as tools in molecular biology, and have potential applications in gene therapy.

See Also

• RNA World Hypothesis
• Catalytic RNA
• Self-splicing Intron
• RNA Splicing

References

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Ribozyme

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  Full length hammerhead ribozyme

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  Ribozyme

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  Ribozyme structure pictures

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  Protein translation