Reverse tolerance

Reverse tolerance or drug sensitization is a pharmacological concept describing subjects' increased reaction (positive or negative) to a drug following its repeated use. This is the opposite of drug tolerance.

Overview

Reverse tolerance is often observed with drugs such as amphetamine, cocaine, and MDMA. It is a key factor in the process of addiction. In some cases, users may not realize they have developed reverse tolerance, leading to an increased risk of overdose.

Mechanism

The exact mechanism of reverse tolerance is not fully understood. It is believed to involve changes in the brain's neurotransmitter systems. These changes may result in increased sensitivity to the effects of a drug, even when the dose remains the same.

Clinical significance

Reverse tolerance has significant implications in the field of addiction medicine. It can lead to increased drug use, as users may take more of the drug to achieve the desired effect. This can result in a higher risk of overdose and other health problems.

See also

• Drug tolerance
• Pharmacology
• Addiction medicine

References

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