Reticulohistiocytoma

Reticulohistiocytoma

Reticulohistiocytoma (pronounced: re-tic-u-lo-his-ti-o-cy-to-ma) is a rare, non-Langerhans cell histiocytosis characterized by the presence of large, multinucleated macrophages and histiocytes in the skin and/or internal organs.

Etymology

The term "Reticulohistiocytoma" is derived from the Latin reticulum meaning "net", and histiocyte, a type of immune cell. The suffix "-oma" is derived from the Greek -oma, meaning "tumor" or "mass".

Definition

Reticulohistiocytoma is a rare type of non-Langerhans cell histiocytosis. It is characterized by the presence of large, multinucleated macrophages and histiocytes in the skin and/or internal organs. The disease can present as a solitary cutaneous lesion (cutaneous reticulohistiocytoma) or as a systemic disease involving multiple organs (multicentric reticulohistiocytoma).

Symptoms

Symptoms of reticulohistiocytoma can vary greatly depending on the location and extent of the disease. Cutaneous reticulohistiocytoma typically presents as a solitary, red-brown nodule or papule on the skin. Multicentric reticulohistiocytoma can involve multiple organs and may present with systemic symptoms such as fever, weight loss, and joint pain.

Diagnosis

Diagnosis of reticulohistiocytoma is typically made through a combination of clinical examination, imaging studies, and histopathological examination of a biopsy specimen. The characteristic histological finding is the presence of large, multinucleated macrophages and histiocytes with a "ground-glass" cytoplasm.

Treatment

Treatment of reticulohistiocytoma is largely dependent on the extent and location of the disease. Localized cutaneous lesions may be treated with surgical excision, while systemic disease may require systemic therapy with corticosteroids, chemotherapy, or targeted therapies.

Related Terms

• Histiocytosis
• Macrophage
• Biopsy
• Chemotherapy
• Corticosteroids

External links

• Medical encyclopedia article on Reticulohistiocytoma
• Wikipedia's article - Reticulohistiocytoma

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