RE1-silencing transcription factor

RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein that in humans is encoded by the REST gene. REST is a transcriptional repressor that regulates gene expression.

Function

REST is a transcription factor that binds to the RE1/NRSE (neuron-restrictive silencer element) and acts as a master negative regulator of the expression of neuronal genes in non-neuronal cells. It represses neuronal genes by recruiting co-repressor complexes.

Structure

The REST protein is composed of an N-terminal MAD homology domain and a C-terminal zinc finger domain. The MAD homology domain is responsible for DNA binding, while the zinc finger domain is involved in protein-protein interactions.

Role in Disease

Alterations in the normal function of REST have been implicated in several diseases, including neurodegenerative diseases, cancer, and mental disorders. For example, in Huntington's disease, REST is mislocalized, leading to deregulation of neuronal genes.

Research

Research into the function and regulation of REST continues to be a significant focus in the field of neuroscience. Understanding the role of REST in disease may lead to the development of novel therapeutic strategies.

See Also

• Transcription factor
• Neuroscience
• Gene expression

References

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RE1-silencing transcription factor

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  3 cofactors

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  Neuron-Restrictive Silencer Factor and cofactors closed state