Pyrantel

Pyrantel

Chemical structure of Pyrantel

Pyrantel is an anthelmintic medication used to treat a variety of parasitic worm infections. It is particularly effective against hookworms and roundworms. Pyrantel works by paralyzing the worms, which are then expelled from the body through the feces.

Mechanism of Action

Pyrantel acts as a neuromuscular blocking agent in susceptible parasites. It causes a depolarizing neuromuscular blockade, leading to spastic paralysis of the worm. This paralysis allows the host's natural peristaltic action to expel the worm from the gastrointestinal tract.

Uses

Pyrantel is commonly used to treat infections caused by:

• Enterobius vermicularis (pinworm)
• Ascaris lumbricoides (roundworm)
• Ancylostoma duodenale and Necator americanus (hookworms)

Administration

Pyrantel is administered orally, often in the form of a pyrantel pamoate suspension or tablet. The dosage is typically based on the patient's weight and the type of infection being treated.

Side Effects

Common side effects of pyrantel may include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal cramps

Serious side effects are rare but can include allergic reactions such as rash, itching, and swelling.

Precautions

Patients with liver disease should use pyrantel with caution. It is also important to follow the prescribed dosage and not to use pyrantel in combination with other anthelmintics unless directed by a healthcare provider.

Related Pages

• Anthelmintic
• Parasitic worm
• Hookworm
• Roundworm