Protein c
Protein C
Protein C (pronounced: pro-teen see) is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
Etymology
The term "Protein C" was coined in 1960 by Seegers, Johnson, and Fell, who observed an unidentified protein (which they named Protein C) that appeared to participate in the blood coagulation process.
Function
Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme that is activated by thrombin into activated Protein C (APC). The activated form (with protein S as a cofactor), degrades Factor Va and Factor VIIIa, reducing the amount of thrombin generated.
Related Terms
- Activated Protein C: The activated form of Protein C.
- Protein S: A cofactor for Protein C.
- Factor Va: A protein that is inactivated by Protein C.
- Factor VIIIa: Another protein that is inactivated by Protein C.
- Thrombin: An enzyme that activates Protein C.
- Vitamin K: A vitamin that is necessary for the production of Protein C.
Deficiency
Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The disease belongs to a group of diseases known as inherited thrombophilia.
See Also
External links
- Medical encyclopedia article on Protein c
- Wikipedia's article - Protein c
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