Profetamine
Profetamine is a psychostimulant and amphetamine derivative that is primarily used for its cognitive enhancing and stimulant effects. It belongs to a class of compounds known as phenethylamines, which are characterized by their ability to increase alertness, energy, and concentration, while also potentially elevating mood. Profetamine, like other amphetamines, works by increasing the levels of several neurotransmitters in the brain, including dopamine, norepinephrine, and serotonin, which are associated with mood regulation, energy levels, and the ability to focus.
Medical Uses
Profetamine is used in the treatment of various medical conditions, primarily those related to attention and focus. The most common indications include:
- Attention Deficit Hyperactivity Disorder (ADHD): Profetamine can help increase attention span, focus, and control impulsivity in individuals with ADHD.
 - Narcolepsy: It may be prescribed to help manage the symptoms of narcolepsy, such as sudden sleep attacks and excessive daytime sleepiness.
 
Mechanism of Action
The mechanism of action of profetamine involves the release of monoamine neurotransmitters from their storage sites in nerve terminals. It primarily increases the release of dopamine and norepinephrine, leading to increased neurotransmitter levels in the synaptic cleft and enhanced stimulation of post-synaptic receptors. This action is believed to contribute to the drug's stimulant effects and its efficacy in treating ADHD and narcolepsy.
Side Effects
As with other stimulant medications, profetamine can cause a range of side effects, which may include:
Long-term use or abuse of profetamine can lead to more severe health issues, including dependency, cardiovascular problems, and mental health disorders such as psychosis.
Contraindications
Profetamine is contraindicated in individuals with a history of substance abuse, cardiovascular diseases, Hyperthyroidism, and Glaucoma. It should be used with caution in patients with a history of mental health disorders, such as Bipolar disorder or depression.
Pharmacokinetics
The pharmacokinetics of profetamine, including its absorption, distribution, metabolism, and excretion, are similar to those of other amphetamines. It is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within a few hours after oral administration. Profetamine is metabolized in the liver and excreted in the urine.
Legal Status
The legal status of profetamine varies by country, but it is commonly classified as a controlled substance due to its potential for abuse and dependency. In many jurisdictions, its use is restricted to prescription by a licensed healthcare provider.
See Also
- Amphetamine
 - Psychostimulant
 - Cognitive enhancement
 - Attention Deficit Hyperactivity Disorder (ADHD)
 - Narcolepsy
 
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Contributors: Prab R. Tumpati, MD