Prodynorphin

Prodynorphin (PDYN) is a protein that in humans is encoded by the PDYN gene. The protein encoded by this gene is a preproprotein that is cleaved to form dynorphin and other related peptides. Dynorphin is thought to be involved in the regulation of perception of pain, and in the establishment of dependency and addiction behaviors.

Function

The human PDYN gene encodes a preproprotein, prodynorphin, which is cleaved during processing to produce the opioid peptides alpha-neoendorphin, dynorphin A, dynorphin B, and big dynorphin. These peptides are ligands for the kappa opioid receptor, and are thought to modulate perceptions of pain and the emotional response to stress. They may also be involved in the regulation of appetite and body temperature, and in the development of dependency and addiction to drugs of abuse.

Clinical significance

Alterations in the PDYN gene have been associated with an increased risk of alcoholism and drug addiction. In addition, mutations in this gene may be involved in the pathogenesis of neurological disorders such as Huntington's disease and Parkinson's disease.

See also

• Dynorphin
• Kappa opioid receptor
• Neuropeptide

External links

• PDYN at the National Center for Biotechnology Information