Portal hypothesis
Portal Hypothesis
Portal Hypothesis (pronunciation: /ˈpɔːrtəl ˈhaɪpɒθɪsɪs/) is a medical theory that suggests a direct link between the gut and the liver through the portal vein, and how this connection influences the development of insulin resistance and type 2 diabetes.
Etymology
The term "portal hypothesis" is derived from the word "portal", which in this context refers to the portal vein, and "hypothesis", a proposed explanation made on the basis of limited evidence as a starting point for further investigation.
Explanation
The portal hypothesis proposes that an increase in the delivery of free fatty acids (FFAs) and other substances from the gut to the liver via the portal vein can lead to hepatic insulin resistance. This, in turn, can result in an increase in hepatic glucose production, contributing to the development of type 2 diabetes.
Related Terms
- Insulin Resistance: A condition in which cells in the body become resistant to the effects of insulin, a hormone that regulates the movement of sugar into cells.
- Type 2 Diabetes: A chronic condition that affects the way the body processes blood sugar (glucose).
- Portal Vein: A major vein that carries blood from the stomach and intestines to the liver.
- Free Fatty Acids (FFAs): Molecules released into the bloodstream as a result of the breakdown of fat tissue.
See Also
External links
- Medical encyclopedia article on Portal hypothesis
- Wikipedia's article - Portal hypothesis
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