Polyhexanide

Polyhexanide

Chemical structure of polyhexanide

Polyhexanide, also known as polyhexamethylene biguanide (PHMB), is a polymeric compound that is widely used for its antimicrobial properties. It is commonly employed in medical, veterinary, and industrial applications due to its effectiveness in killing bacteria, fungi, and viruses.

Chemical Structure

Polyhexanide is a polymer composed of repeating units of biguanide groups linked by hexamethylene chains. The chemical structure of polyhexanide allows it to interact with microbial cell membranes, leading to cell lysis and death. This mechanism of action makes it a potent antimicrobial agent.

Applications

Polyhexanide is used in a variety of applications, including:

• Wound Care: It is used in wound dressings and solutions for its ability to prevent infection and promote healing.
• Contact Lens Solutions: Polyhexanide is an active ingredient in some contact lens cleaning solutions due to its ability to disinfect lenses without causing irritation to the eyes.
• Water Treatment: It is used in swimming pools and water systems to control microbial growth.
• Veterinary Medicine: Polyhexanide is used in veterinary products for the treatment of skin infections and as a disinfectant.

Mechanism of Action

Polyhexanide works by disrupting the cell membranes of microorganisms. The biguanide groups in its structure interact with the phospholipids in the cell membrane, leading to increased permeability and eventual cell death. This action is effective against a broad spectrum of microorganisms, including gram-positive and gram-negative bacteria, fungi, and some viruses.

Safety and Efficacy

Polyhexanide is considered safe for use in humans and animals when used as directed. It is non-toxic and non-irritating, making it suitable for use in sensitive applications such as wound care and ophthalmic solutions. Its efficacy as an antimicrobial agent has been well-documented in various studies.

Related pages

• Antimicrobial agent
• Wound care
• Contact lens solution
• Water treatment