Pipamazine

Pipamazine is a phenothiazine derivative that was used as an antiemetic. It was primarily used in the prevention and treatment of nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. However, it is no longer widely used due to the development of newer, more effective antiemetic drugs.

Etymology

The term "Pipamazine" is derived from the chemical name of the drug, which is N,N-dimethyl-1-phenothiazine-10-ylpropan-2-amine. The "pipa-" prefix is derived from "propan-2-amine", and "-mazine" is a common suffix for phenothiazine derivatives.

Pharmacology

Pipamazine works by blocking the action of a chemical in the brain called dopamine. Dopamine is a neurotransmitter that the brain uses to transmit signals in the brain. By blocking the action of dopamine, pipamazine can prevent the feeling of nausea and the act of vomiting.

Side Effects

Like all medications, pipamazine can cause side effects. Common side effects include drowsiness, dry mouth, and blurred vision. Less common side effects include constipation, difficulty urinating, and changes in heart rhythm. In rare cases, pipamazine can cause a serious condition called neuroleptic malignant syndrome, which is characterized by fever, muscle stiffness, and altered mental status.

Related Terms

• Phenothiazine: A type of chemical compound that is used in many drugs, including pipamazine.
• Antiemetic: A type of drug that is used to prevent or treat nausea and vomiting.
• Dopamine: A neurotransmitter in the brain that is involved in many functions, including the regulation of nausea and vomiting.

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