Pi helix

Pi helix is a type of secondary structure found in proteins. It is less common than the alpha helix and the beta sheet structures but plays a crucial role in the folding and function of some proteins. The Pi helix is characterized by its unique hydrogen bonding pattern and the number of amino acids per turn.

Structure

The Pi helix consists of 4.4 residues per turn, compared to 3.6 residues per turn in the alpha helix. This results in a tighter helical structure with a pitch of approximately 5.2 Å, which is longer than that of the alpha helix. The hydrogen bonds in a Pi helix are formed between the carbonyl oxygen of one amino acid and the amide hydrogen of another, typically four residues away. This pattern of hydrogen bonding stabilizes the helical structure.

Function

The specific role of Pi helices in proteins is not as well understood as that of alpha helices and beta sheets. However, they are thought to contribute to the stability and flexibility of protein structures. In some cases, Pi helices have been found to participate in the active sites of enzymes, suggesting a role in catalysis. They may also be involved in protein-protein interactions and the binding of small molecules.

Examples

One notable example of a protein that contains a Pi helix is the hemoglobin molecule. In hemoglobin, the Pi helix is involved in the binding of oxygen molecules, which is essential for the protein's function in oxygen transport in the blood.

Comparison with Other Helices

In addition to the alpha helix, there are other types of helices found in proteins, such as the 3_10 helix. The 3_10 helix has 3 residues per turn and a tighter coil than the alpha helix. The Pi helix, with its 4.4 residues per turn, is less common but provides a unique structural feature that can be critical for the specific function of certain proteins.

Research and Implications

Understanding the structure and function of Pi helices can have significant implications for the field of biochemistry and molecular biology. It can aid in the design of synthetic peptides and proteins with specific functions, which has applications in drug development and biotechnology.

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  Side view of Pi helix

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  Top view of Pi helix

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  Pi helix within an alpha helix