Phospholipase a2
Phospholipase A2
Phospholipase A2 (pronunciation: fos-fo-li-pase A2) is a type of enzyme that is involved in the metabolism of phospholipids. It is part of the larger family of phospholipases, which are enzymes that cleave phospholipids. Specifically, phospholipase A2 catalyzes the hydrolysis of the sn-2 acyl chain, releasing arachidonic acid and lysophospholipid.
Etymology
The term "phospholipase A2" is derived from the type of reaction it catalyzes. "Phospho-" refers to the involvement of a phosphate group, "-lipase" indicates that it is an enzyme that breaks down lipids, and "A2" specifies the particular position on the phospholipid molecule where the enzyme acts.
Function
Phospholipase A2 plays a crucial role in the biosynthesis of eicosanoids, which are signaling molecules that mediate inflammatory and anaphylactic reactions. It is also involved in the production of prostaglandins and leukotrienes, which are important for immune responses.
Related Terms
- Arachidonic acid
- Eicosanoids
- Enzyme
- Leukotrienes
- Lipids
- Lysophospholipid
- Metabolism
- Phosphate
- Phospholipids
- Prostaglandins
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