Persephin

Persephin is a neurotrophic factor that is part of the glial cell line-derived neurotrophic factor (GDNF) family of ligands. It is encoded by the PSPN gene in humans. Persephin promotes the survival of certain types of sensory and sympathetic neurons.

Function

Persephin is a protein that is highly similar to other members of the GDNF family. It is a potent survival factor for certain neuronal cell populations. One of these populations is the motor neurons, which are vital for the control of muscle movement. Persephin also promotes the survival of dopaminergic neurons, which are involved in the regulation of movement, mood, and reward.

Clinical significance

Persephin has been implicated in several neurodegenerative diseases, including Parkinson's disease and Amyotrophic lateral sclerosis (ALS). In Parkinson's disease, the death of dopaminergic neurons leads to the symptoms of the disease. Persephin has been shown to promote the survival of these neurons, suggesting a potential therapeutic role. In ALS, the death of motor neurons leads to muscle weakness and paralysis. Persephin may also have a protective effect in this disease.

See also

• Neurotrophic factor
• Glial cell line-derived neurotrophic factor
• Motor neuron
• Dopaminergic

References

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