Penicilloic acid
Penicilloic acid is a metabolite of the antibiotic penicillin. It is formed by the enzymatic action of penicillinase, an enzyme that breaks down penicillin. Penicilloic acid is inactive, meaning it does not have the antibiotic properties of penicillin.
Structure and Properties
Penicilloic acid has a similar structure to penicillin, but with a broken beta-lactam ring. This ring is crucial for the antibiotic activity of penicillin. The breaking of the beta-lactam ring results in the loss of antibiotic activity, making penicilloic acid an inactive metabolite.
Formation
Penicilloic acid is formed by the action of the enzyme penicillinase on penicillin. Penicillinase is a type of beta-lactamase, a class of enzymes that are capable of breaking the beta-lactam ring of penicillin and other beta-lactam antibiotics. This enzymatic action is a common mechanism of antibiotic resistance in many bacteria.
Clinical Significance
The formation of penicilloic acid is significant in the clinical setting as it is a major mechanism of resistance to penicillin in many bacterial species. Bacteria that produce penicillinase can break down penicillin into penicilloic acid, rendering the antibiotic ineffective. This has led to the development of penicillinase-resistant penicillins, such as methicillin and oxacillin, which are not broken down by the enzyme.
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