Paratyphoid fever

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Paratyphoid fever
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Fever, abdominal pain, diarrhea, headache
Complications	Intestinal perforation, sepsis
Onset	6–30 days after exposure
Duration	Several weeks
Types	N/A
Causes	Salmonella enterica serovars Paratyphi A, Paratyphi B, Paratyphi C
Risks	Travel to areas with poor sanitation
Diagnosis	Blood culture, stool culture
Differential diagnosis	Typhoid fever, malaria, dengue fever
Prevention	Vaccination, sanitation, handwashing
Treatment	Antibiotics such as ciprofloxacin, azithromycin
Medication
Prognosis	Generally good with treatment
Frequency	5 million cases per year
Deaths	50,000 deaths per year

Paratyphoid fever is an infectious disease caused by certain strains of the Salmonella bacteria. It presents clinical symptoms resembling those of typhoid fever but is generally considered less severe. Like typhoid, paratyphoid fever primarily affects the intestines and is associated with contaminated food or water sources.

Introduction

Paratyphoid fever, similar to typhoid, is transmitted through the fecal-oral route. The disease is often linked to poor sanitation and the consumption of contaminated food or water. It's especially prevalent in regions where sanitary practices might be compromised.

Causative Agent

The disease is caused by strains of Salmonella enterica – specifically serotypes Paratyphi A, B, and C.

Symptoms

Patients with paratyphoid fever typically exhibit:

• High fever
• Abdominal pain
• Headache
• Rashes
• Loss of appetite
• Malaise
• Diarrhea or constipation

Diagnosis

Diagnosis of paratyphoid fever includes:

• Blood cultures: To detect the presence of Salmonella spp.
• Stool and urine tests: For identifying the bacteria.
• Bone marrow test: A more accurate but less common test to detect Salmonella.

Treatment

The treatment strategy for paratyphoid fever largely mirrors that of typhoid:

• Antibiotics: Ciprofloxacin, ceftriaxone, and azithromycin are commonly prescribed.
• Hydration: Patients might require rehydration, either orally or intravenously.
• Rest: Ensuring the body gets enough rest to recover.

Prevention

Preventative measures include:

• Vaccination: While there's a vaccine for typhoid, no vaccine is available for paratyphoid as of the last update.
• Sanitation: Ensuring safe drinking water and practicing good hygiene.
• Safe food practices: Consuming well-cooked food, avoiding raw fruits and vegetables unless they can be peeled, and avoiding street food in areas where the disease is prevalent.

Prognosis

With prompt and proper treatment, most patients recover fully. However, untreated paratyphoid can lead to complications, which can be severe.

References

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