Palovarotene
Palovarotene
Palovarotene (pronunciation: puh-loh-vuh-roh-teen) is a retinoic acid receptor gamma agonist that is used in the treatment of Fibrodysplasia Ossificans Progressiva (FOP) and Multiple Osteochondromas (MO).
Etymology
The term "Palovarotene" is derived from the words "palov" and "rotene". "Palov" is a term of unknown origin, while "rotene" is a suffix commonly used in the naming of retinoids, a class of chemical compounds that are vitamers of Vitamin A or are chemically related to it.
Usage
Palovarotene is used in the treatment of rare bone disorders such as Fibrodysplasia Ossificans Progressiva (FOP) and Multiple Osteochondromas (MO). FOP is a disorder in which skeletal muscle and connective tissue, such as tendons and ligaments, are gradually replaced by bone (ossified), forming bone outside the skeleton (extra-skeletal or heterotopic bone) that constrains movement. MO, on the other hand, is a condition that causes growths of bone covered by a cap of cartilage, called osteochondromas, to develop on the long bones of the arms, legs, and digits.
Mechanism of Action
Palovarotene works by binding to and activating the retinoic acid receptor gamma (RAR-γ), which is a type of nuclear receptor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. This activation inhibits the bone morphogenetic protein (BMP) signaling pathway, which is overactive in people with FOP and MO. By inhibiting this pathway, palovarotene can reduce the formation of new heterotopic bone and osteochondromas.
Related Terms
- Retinoic Acid
- Retinoic Acid Receptor
- Fibrodysplasia Ossificans Progressiva
- Multiple Osteochondromas
- Vitamin A
- Bone Morphogenetic Protein
- Nuclear Receptor
External links
- Medical encyclopedia article on Palovarotene
- Wikipedia's article - Palovarotene
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski