Palmitoylcarnitine

Palmitoylcarnitine (pronunciation: pal-mi-toy-l-car-ni-tine) is a long-chain acylcarnitine molecule involved in the transport of long-chain fatty acids into the mitochondria for beta-oxidation.

Etymology

The term "Palmitoylcarnitine" is derived from two components: "Palmitoyl" and "Carnitine". "Palmitoyl" refers to the palmitic acid component of the molecule, which is a common saturated fatty acid. "Carnitine" is derived from the Latin carnus, meaning "flesh", as it was first isolated from meat.

Function

Palmitoylcarnitine plays a crucial role in the metabolism of long-chain fatty acids. It is synthesized in the cytosol from palmitoyl-CoA and carnitine by the enzyme carnitine palmitoyltransferase I (CPT I). Once formed, it is transported into the mitochondria by the carnitine-acylcarnitine translocase (CACT). Inside the mitochondria, palmitoylcarnitine is converted back to palmitoyl-CoA and carnitine by carnitine palmitoyltransferase II (CPT II), allowing the fatty acid to undergo beta-oxidation for energy production.

Related Terms

External links

Medical encyclopedia article on Palmitoylcarnitine
Wikipedia's article - Palmitoylcarnitine

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Palmitoylcarnitine