Palladin
Palladin
Palladin (pronounced: /pæləˈdiːn/) is a protein that in humans is encoded by the PALLD gene. It plays a crucial role in the organization of the cytoskeleton and cell adhesion.
Etymology
The term "Palladin" is derived from the Latin word "palladium", which means "safeguard or source of protection". This is in reference to the protein's role in maintaining the structural integrity of cells.
Function
Palladin is a cytoskeletal protein that is involved in the organization of actin filaments. It is a component of stress fibers, which are contractile structures that appear in cells in response to mechanical stress. Palladin also plays a role in the formation of lamellipodia and filopodia, which are cellular structures involved in cell movement and adhesion.
Clinical significance
Mutations in the PALLD gene that encodes palladin have been associated with familial pancreatic cancer and idiopathic scoliosis. Overexpression of palladin has been observed in several types of cancer, including breast, lung, and pancreatic cancer, suggesting that it may play a role in tumor progression.
Related terms
External links
- Medical encyclopedia article on Palladin
- Wikipedia's article - Palladin
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