PIAS1

PIAS1 is a protein that in humans is encoded by the PIAS1 gene. PIAS1 is a member of the protein inhibitor of activated STAT (PIAS) family. These proteins function as SUMO E3 ligases and regulate transcriptional activities of various transcription factors and steroid receptors.

Function

PIAS1 is a member of the protein inhibitor of activated STAT (PIAS) family. The members of this family function as SUMO E3 ligases and regulate the transcriptional activities of various transcription factors and steroid receptors. PIAS1 interacts with STAT1 and blocks its transcriptional activity by preventing its binding to DNA. It also interacts with the androgen receptor (AR) and enhances AR-mediated transcription. PIAS1 can also bind to the p53 protein and inhibit its function, thus regulating cell growth and apoptosis.

Clinical significance

Mutations in the PIAS1 gene have been associated with cancer, particularly breast cancer and prostate cancer. The protein's interaction with p53 and the androgen receptor suggests that it may play a role in the development and progression of these cancers.

Interactions

PIAS1 has been shown to interact with:

• STAT1
• Androgen receptor
• p53

References

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External links

• PIAS1 at the National Center for Biotechnology Information

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