PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair and programmed cell death.

Function

The PARP family of proteins are involved in a number of cellular processes, most notably DNA repair and programmed cell death. The function of these proteins is to transfer ADP-ribose to target proteins. This process, known as ADP-ribosylation, can result in the modification of protein function.

Structure

The PARP family of proteins are characterized by the presence of a catalytic domain that is capable of transferring ADP-ribose to target proteins. This domain is highly conserved among the different members of the family.

Clinical significance

PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase. They are used in cancer treatment, where they inhibit the repair of DNA damage in cancer cells, leading to their death.

See also

• DNA repair
• Programmed cell death
• ADP-ribosylation
• PARP inhibitor