P73
P73
P73 (pronounced: pee-seventy-three) is a term used in the field of genetics and molecular biology to refer to a specific tumor suppressor gene.
Etymology
The term "P73" is derived from the scientific nomenclature used in genetics. The "P" stands for "protein" and "73" refers to the molecular weight of the protein in kilodaltons.
Definition
P73 is a member of the p53 family of transcription factors. Like the other members of this family, P73 plays a crucial role in the regulation of the cell cycle and thus prevents cancer. It is capable of inducing apoptosis, or programmed cell death, and operates in a network with other similar proteins to ensure the integrity of the genome.
Related Terms
- p53: A tumor suppressor protein that in humans is encoded by the TP53 gene. P53 regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer.
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms. It is a mechanism that leads to the elimination of cells without releasing harmful substances into the surrounding area.
- Cell cycle: The series of events that take place in a cell leading to its division and duplication. Regulation of the cell cycle involves processes crucial to survival, including the detection and repair of genetic damage and the prevention of uncontrolled cell growth.
- Tumor suppressor gene: A gene that protects a cell from one step on the path to cancer. When this gene mutates to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
External links
- Medical encyclopedia article on P73
- Wikipedia's article - P73
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