OR10A3

OR10A3 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in the nose, and is the largest gene family in the mammalian genome. The OR10A3 gene is specifically involved in the detection of certain odorants, and variations in this gene can affect an individual's sense of smell.

Structure

The OR10A3 gene is located on chromosome 1, specifically at 1q44. It spans approximately 1 kilobase and contains one exon. The encoded protein is a member of the olfactory receptor family, and like other members of this family, it is a G-protein coupled receptor. This means that it spans the cell membrane seven times and is coupled to a G-protein on the inside of the cell. When an odorant binds to the receptor, it triggers a cascade of events inside the cell that ultimately leads to the perception of smell.

Function

The primary function of the OR10A3 gene is to encode a protein that can detect certain odorants. When an odorant binds to the OR10A3 protein, it causes a conformational change in the protein that allows it to activate a G-protein. This G-protein then triggers a series of events inside the cell that ultimately leads to the perception of smell. The specific odorants that the OR10A3 protein can detect are not fully known, but research suggests that it may be involved in the detection of certain floral and fruity smells.

Clinical significance

Variations in the OR10A3 gene can affect an individual's sense of smell. For example, certain mutations in this gene can lead to a reduced ability to detect certain smells, a condition known as anosmia. On the other hand, other mutations can lead to an enhanced ability to detect certain smells, a condition known as hyperosmia. Further research is needed to fully understand the clinical significance of the OR10A3 gene.

See also

• Olfactory receptor
• Anosmia
• Hyperosmia

References

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