Null allele
Null allele
A Null allele (pronounced: /nʌl əˈliːl/) is a type of allele that results in the non-production of the associated protein product. The term "null" refers to the absence of function, as these alleles do not produce a working product. This can occur due to a variety of reasons, such as mutations that lead to a stop codon in the coding sequence of the DNA.
Etymology
The term "Null allele" is derived from the Latin word "nullus" meaning "not any", and the Greek word "allelos" meaning "of each other". It was first used in the field of genetics to describe a type of allele that does not produce a functional protein product.
Related Terms
- Allele: One of two or more versions of a gene that are found at the same place on a chromosome.
- Mutation: A change in the DNA sequence that can lead to different variations of a gene, including null alleles.
- Protein: A complex molecule that is the end product of gene expression. Null alleles do not produce a functional protein.
- DNA: The molecule that carries genetic instructions in all living organisms. Mutations in the DNA sequence can lead to null alleles.
- Stop codon: A nucleotide triplet within mRNA that signals the end of translation. Mutations that lead to a stop codon in the coding sequence can result in a null allele.
External links
- Medical encyclopedia article on Null allele
- Wikipedia's article - Null allele
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