Nucleoporin 160

Nucleoporin 160 (NUP160) is a protein that in humans is encoded by the NUP160 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm in eukaryotic cells.

Function

NUP160 is one of the approximately 30 proteins that make up the nuclear pore complex. This complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. NUP160 is located on the cytoplasmic side of the nuclear pore complex and plays a crucial role in the import and export of proteins and RNAs, as well as the biogenesis of the nuclear envelope.

Structure

The NUP160 protein is a member of the Nup107-160 subcomplex, which also includes NUP107, NUP133, NUP85, NUP96, NUP37, SEH1, and SEC13. This subcomplex is thought to play a role in anchoring the nuclear pore complex to the nuclear envelope. The NUP160 protein itself is composed of multiple coiled-coil domains, which are thought to mediate protein-protein interactions.

Clinical significance

Mutations in the NUP160 gene have been associated with Spermatogenic failure 16, a condition characterized by male infertility due to a defect in sperm production.

See also

• Nuclear pore
• Nucleoporin
• Nup107-160 subcomplex

References

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