Norendoxifen

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Norendoxifen (pronounced: nor-en-dox-i-fen) is a metabolite of the drug tamoxifen, which is commonly used in the treatment of breast cancer.

Etymology

The term "Norendoxifen" is derived from the parent drug "Tamoxifen". The prefix "Nor" is a common term in organic chemistry, indicating that a molecule is a demethylated derivative of a parent compound. In this case, Norendoxifen is a demethylated form of Endoxifen, another metabolite of Tamoxifen.

Pharmacology

Norendoxifen is a Selective Estrogen Receptor Modulator (SERM), similar to its parent drug Tamoxifen. It works by binding to estrogen receptors in the body, blocking the effects of estrogen and thereby inhibiting the growth of hormone-responsive cancer cells.

Clinical Use

Norendoxifen, like Tamoxifen, is used in the treatment of estrogen receptor-positive breast cancer. It may also have potential use in the treatment of other hormone-responsive cancers.

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