Non-nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a type of antiretroviral drug used in the treatment of HIV and AIDS.
Pronunciation
Non-nucleoside reverse transcriptase inhibitors: /nɒnˌnjuːklɪəsaɪd rɪˈvɜːs trænˈskrɪptəs ɪnˈhɪbɪtəz/
Etymology
The term "Non-nucleoside reverse transcriptase inhibitors" is derived from the function of the drug. "Non-nucleoside" refers to the fact that these drugs do not contain a nucleoside structure, "reverse transcriptase inhibitors" refers to the enzyme they inhibit, which is crucial for the replication of HIV.
Function
NNRTIs work by binding to and inhibiting the function of the reverse transcriptase enzyme, a protein that HIV needs to replicate itself. By blocking this enzyme, NNRTIs prevent HIV from multiplying and can reduce the amount of the virus in the body.
Examples
Examples of NNRTIs include Efavirenz (EFV), Nevirapine (NVP), and Rilpivirine (RPV). These drugs are often used in combination with other antiretroviral drugs as part of an antiretroviral therapy (ART) regimen.
Side Effects
Like all medications, NNRTIs can cause side effects. Common side effects include rash, fatigue, and gastrointestinal problems such as nausea, vomiting, and diarrhea. Some NNRTIs can also cause serious side effects, such as liver damage or severe skin reactions.
Related Terms
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