Next-generation sequencing
Next-generation sequencing
Next-generation sequencing (pronunciation: /nɛkstˈdʒɛnəˌreɪʃən ˈsiːkwənsɪŋ/), often abbreviated as NGS, is a high-throughput methodology that enables rapid sequencing of the base pairs in DNA or RNA samples. It is also known as massively parallel sequencing.
Etymology
The term "next-generation" refers to the technological advancements beyond the initial sequencing technology, Sanger sequencing. The "sequencing" part of the term refers to the process of determining the exact order of the nucleotides within a DNA molecule.
Description
Next-generation sequencing has revolutionized genomics and molecular biology. The technology allows for sequencing of DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such has broadened the range of applications of genome sequencing.
Applications
NGS has a wide range of applications including genomic sequencing, metagenomics, epigenomics, RNA sequencing, and others. It is used in personalized medicine, forensic science, anthropology, and other fields.
Related Terms
- Genomics: The study of the genomes of organisms.
- Metagenomics: The study of genetic material recovered directly from environmental samples.
- Epigenomics: The study of the complete set of epigenetic modifications on the genetic material of a cell.
- RNA sequencing: The technique used to determine the sequence of an RNA molecule.
See Also
External links
- Medical encyclopedia article on Next-generation sequencing
- Wikipedia's article - Next-generation sequencing
This WikiMD article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski