Neurolathyrism
Neurolathyrism (pronounced: neuro-lath-yr-ism, /ˌnʊəroʊˈlæθərɪzəm/) is a neurological disease caused by the prolonged consumption of the grass pea, also known as Lathyrus sativus. The term "neurolathyrism" is derived from the Greek words "neuro" (nerve) and "lathyrus" (a type of pea).
Definition
Neurolathyrism is a type of neurotoxicity that results from the consumption of the grass pea, especially during times of famine or food scarcity. The disease is characterized by spastic paraparesis, or stiffness and weakness in the lower limbs.
Causes
The primary cause of neurolathyrism is the consumption of the grass pea, which contains a neurotoxic amino acid called ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid). When consumed in large quantities over a prolonged period, ODAP can cause irreversible damage to the motor neurons in the spinal cord, leading to the symptoms of neurolathyrism.
Symptoms
The main symptom of neurolathyrism is spastic paraparesis, which is characterized by stiffness and weakness in the lower limbs. Other symptoms may include muscle pain, cramps, and difficulty walking. In severe cases, the disease can lead to complete paralysis of the lower limbs.
Treatment
There is currently no cure for neurolathyrism, and treatment is primarily focused on managing symptoms and preventing further damage. This may include physical therapy to improve mobility and strength, as well as medication to manage pain and muscle stiffness.
Prevention
The best way to prevent neurolathyrism is to avoid consuming the grass pea, especially in large quantities over a prolonged period. In areas where the grass pea is a staple food, efforts should be made to diversify the diet and reduce dependence on this single food source.
See also
External links
- Medical encyclopedia article on Neurolathyrism
- Wikipedia's article - Neurolathyrism
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