Neovascularization

Neovascularization (pronunciation: /ˌniːoʊˌvæskjʊləraɪˈzeɪʃən/) is a natural process in the body where new blood vessels form from pre-existing vessels. The term is derived from the Greek words 'neo' meaning new, and 'vascular' referring to the vessels, and 'ization' which denotes a process.

Process

Neovascularization is a crucial process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitors in the treatment of cancer.

Types

There are two types of neovascularization: angiogenesis and vasculogenesis. Angiogenesis is the formation of new blood vessels from pre-existing ones, while vasculogenesis is the formation of new blood vessels where there were none before.

Clinical Significance

Neovascularization plays a significant role in several diseases such as diabetic retinopathy, macular degeneration, cancer, and rheumatoid arthritis. In these conditions, the process of neovascularization can lead to further disease progression and complications.

Treatment

Treatment of conditions involving neovascularization often involves the use of angiogenesis inhibitors, which are drugs that inhibit the growth of new blood vessels. These drugs are commonly used in the treatment of cancer and certain eye diseases.

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Neovascularization