NK012
NK012 is a nanoparticle drug delivery system that is used to deliver SN-38, the active metabolite of Irinotecan. It was developed by Nippon Kayaku.
Mechanism of action[edit]
NK012 is a polymer-drug conjugate that uses a polyglutamic acid (PGA) polymer to deliver SN-38. The PGA polymer is linked to SN-38 via a ester bond, which is cleaved in the body to release the active drug. The nanoparticle formulation allows for a higher concentration of the drug to be delivered to tumor cells, while reducing the exposure of healthy cells to the drug.
Clinical trials[edit]
NK012 has been tested in clinical trials for various types of cancer, including colorectal cancer, non-small cell lung cancer, and ovarian cancer. In a phase I clinical trial, NK012 showed promising results in patients with advanced solid tumors. However, in a phase II clinical trial for non-small cell lung cancer, the drug did not meet its primary endpoint of improving progression-free survival.
Side effects[edit]
The most common side effects of NK012 are neutropenia, diarrhea, and fatigue. Severe neutropenia was reported in a significant number of patients in clinical trials.
See also[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
| This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
