NASH

Non-alcoholic steatohepatitis (NASH) is a type of fatty liver disease, characterized by inflammation and accumulation of fat in the liver. It is most commonly associated with obesity, insulin resistance, metabolic syndrome, and/or a diet high in fructose/sugar.

Symptoms

NASH is usually asymptomatic in its early stages. However, as the disease progresses, symptoms may include fatigue, weakness, weight loss, jaundice, and abdominal pain. In severe cases, NASH can lead to cirrhosis, liver failure, or liver cancer.

Causes

The exact cause of NASH is unknown, but it is often associated with conditions that increase the risk of heart disease, such as obesity, high cholesterol, and type 2 diabetes. Other risk factors include poor diet, lack of physical activity, and certain genetic factors.

Diagnosis

NASH is typically diagnosed through a combination of blood tests, imaging studies, and liver biopsy. Blood tests may show elevated liver enzymes, while imaging studies such as ultrasound or CT scan can reveal fat accumulation in the liver. A liver biopsy is the most definitive test, allowing for direct examination of the liver tissue.

Treatment

There is currently no specific treatment for NASH. Management primarily involves lifestyle modifications, such as weight loss, healthy diet, and regular exercise. In some cases, medication may be used to control associated conditions such as diabetes or high cholesterol.

Prognosis

The prognosis for NASH varies depending on the stage of the disease and the individual's overall health. Early detection and management can slow the progression of the disease and reduce the risk of complications.

See also

• Fatty liver
• Alcoholic liver disease
• Cirrhosis
• Liver cancer

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