Muse cell

Muse Cell

Muse cells (pronounced: myooz cells) are non-tumorigenic pluripotent stem cells that can self-renew and differentiate into cells from all three germ layers. They were first discovered in 2010 by a team of researchers led by Mari Dezawa.

Etymology

The term "Muse" is an acronym for "Multilineage-differentiating Stress Enduring" cells. It was chosen to reflect the cells' ability to withstand stress and differentiate into multiple cell types.

Definition

Muse cells are a type of stem cell that exist in various tissues in the body, including the bone marrow, skin, and adipose tissue. They are unique in their ability to withstand stress, such as low oxygen levels and high cell density, and still maintain their pluripotency. This means they can differentiate into any cell type in the body, making them a promising tool for regenerative medicine.

Characteristics

Muse cells are characterized by their expression of pluripotency markers, such as SSEA-3, TRA-1-60, and TRA-1-81. They also express the mesenchymal stem cell marker CD105. Unlike other stem cells, Muse cells do not form tumors when transplanted into the body, making them a safer option for stem cell therapy.

Applications

Due to their pluripotency and non-tumorigenic nature, Muse cells have potential applications in various fields of medicine. They could be used in regenerative medicine to replace damaged or lost cells, in drug discovery for testing new drugs, and in disease modeling to study the mechanisms of various diseases.

Related Terms

• Stem cell
• Pluripotency
• Regenerative medicine
• SSEA-3
• TRA-1-60
• TRA-1-81
• CD105

External links

• Medical encyclopedia article on Muse cell
• Wikipedia's article - Muse cell

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