Melatonin receptor 1B
Melatonin receptor 1B (also known as MTNR1B) is a protein that in humans is encoded by the MTNR1B gene. It is one of the two high-affinity forms of serotonin receptors found in the pineal gland and the retina.
Function[edit]
The MTNR1B receptor is a member of the G protein-coupled receptor family and is an integral part of the melatonin signal transduction pathway. Melatonin is a hormone produced in the pineal gland and is involved in the regulation of circadian rhythms. The MTNR1B receptor is thought to influence a variety of biological functions, including sleep, mood, and immune system function.
Clinical significance[edit]
Mutations in the MTNR1B gene have been associated with an increased risk of type 2 diabetes. This is thought to be due to the role of melatonin in regulating insulin secretion. Additionally, variations in the MTNR1B gene have been linked to polycystic ovary syndrome (PCOS), suggesting a role for this receptor in reproductive function.
See also[edit]
References[edit]
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External links[edit]
- MTNR1B at the National Center for Biotechnology Information
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