Mean platelet volume

Mean Platelet Volume (MPV)

Introduction

Mean Platelet Volume (MPV) is a laboratory measurement that determines the average size of platelets in a blood sample. Platelets, or thrombocytes, are small blood cells essential for normal blood clotting and wound healing processes. MPV is a part of the complete blood count (CBC) and provides valuable information about platelet production and function.

Significance of MPV

MPV is an important diagnostic tool in evaluating patients with various hematological and cardiovascular disorders. It helps in the assessment of:

• Platelet production in the bone marrow.
• The risk of diseases such as stroke, myocardial infarction, and thrombosis.
• The effectiveness of certain treatments affecting platelet count and size.

Measurement and Interpretation

MPV is measured in femtoliters (fL) and is typically calculated by automated blood analyzers. The normal range for MPV varies, but it is generally between 7.5 and 11.5 fL. Values outside this range may indicate medical conditions that affect platelet production or lifespan.

Blood smear under a microscope showing platelets.

Clinical Relevance

Elevated or decreased MPV values can be indicative of various conditions:

Elevated MPV

High MPV values may suggest an increased risk of cardiovascular diseases and can be associated with conditions like diabetes mellitus, hyperthyroidism, or myeloproliferative diseases.

Decreased MPV

Low MPV values may be seen in conditions such as aplastic anemia, cirrhosis, or following chemotherapy.

Factors Influencing MPV

Several factors can affect MPV values, including inflammation, medication, spleen function, and genetic factors.

MPV in Disease Management

Monitoring MPV can be crucial in the management of certain diseases, providing insights into the prognosis and guiding treatment decisions.

See Also

• Complete blood count
• Platelet
• Hematology

References

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 Mean platelet volume: a link between thrombosis and inflammation?, 
 Circulation, 
 2011,

Mean Platelet Volume(link). {{{website}}}. Mayo Clinic Laboratories.

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External Links

• American Association for Clinical Chemistry
• American Society of Hematology