Mad2
Mad2
Mad2 (pronounced: "mad two"), also known as Mitotic Arrest Deficient 2, is a protein that in humans is encoded by the MAD2L1 gene. It is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.
Etymology
The term "Mad2" is derived from the phrase "Mitotic Arrest Deficient 2". The name reflects the protein's role in cell division, specifically in the mitotic phase of the cell cycle.
Function
Mad2 is a key component of the spindle assembly checkpoint. This checkpoint ensures that all chromosomes are properly attached to the spindle apparatus before the cell proceeds to anaphase. If a chromosome is not properly attached, Mad2 inhibits the anaphase-promoting complex (APC/C), preventing the cell from progressing to anaphase.
Related Terms
- Mitosis: The process of cell division that results in two daughter cells each having the same number and kind of chromosomes as the parent nucleus.
- Anaphase: The stage of mitosis or meiosis when chromosomes are split and the sister chromatids move to opposite poles of the cell.
- Metaphase: The stage of mitosis in the eukaryotic cell cycle in which chromosomes are at their second-most condensed and coiled stage.
- Spindle apparatus: The cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
- Anaphase-promoting complex (APC/C): An E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome.
External links
- Medical encyclopedia article on Mad2
- Wikipedia's article - Mad2
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski