MTA2

MTA2 is a protein that in humans is encoded by the MTA2 gene. It is a part of the metastasis-associated protein family, which is involved in a variety of cellular processes such as cell cycle progression, DNA repair, and transcription regulation.

Function

MTA2 is a component of the nucleosome remodeling and deacetylase (NuRD) complex, which is involved in the remodeling of chromatin by deacetylating histones. This process is crucial for transcriptional regulation, cell cycle progression, and developmental events. MTA2 is known to interact with other proteins in the NuRD complex, such as HDAC1 and HDAC2, to carry out its function.

Clinical Significance

Alterations in the expression of MTA2 have been associated with various types of cancer, including breast cancer, prostate cancer, and colorectal cancer. Overexpression of MTA2 has been linked to increased cell proliferation and invasion, suggesting a role in tumor progression and metastasis.

Research

Research into the role of MTA2 in cancer progression and potential therapeutic interventions is ongoing. Studies have suggested that targeting MTA2 could be a potential strategy for cancer treatment, although further research is needed to fully understand the mechanisms involved.

See Also

• MTA1
• MTA3
• Nucleosome remodeling
• Histone deacetylase

References

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