MOBKL1A

MOBKL1A, also known as MOB kinase activator 1A, is a protein that in humans is encoded by the MOB1A gene. It is a core component of the hippo signaling pathway, which plays a crucial role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

Function

MOBKL1A is a key regulator of the mitotic exit network (MEN) and the hippo signaling pathway. It is involved in the regulation of cell cycle and cell proliferation, and its dysregulation can lead to cancer. MOBKL1A is also involved in cell polarity and cell migration, which are important for tissue development and homeostasis.

Structure

The MOBKL1A protein consists of 216 amino acids and has a molecular weight of approximately 24.5 kDa. It contains a MOB domain, which is a conserved protein domain found in all eukaryotes. The MOB domain is responsible for binding to other proteins and is essential for the function of MOBKL1A.

Clinical significance

Mutations in the MOB1A gene can lead to various types of cancer, including breast cancer, colorectal cancer, and hepatocellular carcinoma. In addition, MOBKL1A has been implicated in neurodegenerative diseases due to its role in regulating neuronal cell death.

Research

Research on MOBKL1A is ongoing, with studies focusing on its role in cancer and neurodegenerative diseases. Understanding the function and regulation of MOBKL1A could lead to the development of new therapeutic strategies for these diseases.

See also

• MOB kinase activator
• Hippo signaling pathway
• Mitotic exit network

References

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