Loss of heterozygosity
Loss of heterozygosity (LOH) is a genetic event that results in the loss of normal function of one allele of a gene where the other allele was already inactivated.
Pronunciation
- Loss of heterozygosity: /ˈlɒs ɒv ˌhɛtərəˈzɒɡəsi/
Etymology
The term "Loss of heterozygosity" is derived from the field of genetics. "Loss" refers to the disappearance or reduction of something. "Heterozygosity" is a term used in genetics to describe a state where an individual has different alleles at a gene locus.
Definition
In the context of genetics, Loss of heterozygosity (LOH) refers to the event that leads to the loss of the normal function of one allele of a gene when the other allele was already inactivated. This event is significant in the development of many types of cancer.
Related Terms
See Also
References
External links
- Medical encyclopedia article on Loss of heterozygosity
- Wikipedia's article - Loss of heterozygosity
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