Linzagolix
Linzagolix is a gonadotropin-releasing hormone antagonist (GnRH antagonist) that is used in the treatment of endometriosis and uterine fibroids. It is developed by ObsEva, a Swiss biopharmaceutical company.
Mechanism of action
Linzagolix works by blocking the gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. This prevents the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn reduces the production of estrogen by the ovaries. The reduction in estrogen levels helps to shrink endometriosis lesions and uterine fibroids.
Clinical trials
Linzagolix has undergone several clinical trials to evaluate its safety and efficacy. The Phase 3 EDELWEISS trial evaluated the efficacy and safety of linzagolix in women with endometriosis-associated pain. The PRIMROSE trials evaluated the efficacy and safety of linzagolix in women with heavy menstrual bleeding associated with uterine fibroids.
Side effects
Common side effects of linzagolix include hot flashes, insomnia, and mood swings. Less common but more serious side effects can include bone loss due to the reduction in estrogen levels.
See also
| GnRH antagonists | ||||||
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| Endometriosis | ||||||||
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This Endometriosis related article is a stub.
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Linzagolix chemical structure
Linzagolix molecule ball-and-stick model
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Contributors: Prab R. Tumpati, MD
