Latanoprostene bunod

Latanoprostene Bunod

Latanoprostene bunod (pronunciation: la-TAN-oh-PROS-teen BYOO-nod) is a medication used in the treatment of glaucoma and high pressure in the eye. It is a prodrug of latanoprost and nitric oxide.

Etymology

The name "Latanoprostene bunod" is derived from its parent drug, latanoprost, and the term "bunod" which is an acronym for "butanediol mononitrate donor". This refers to the drug's ability to donate nitric oxide, a property that is unique among glaucoma medications.

Pharmacology

Latanoprostene bunod is a nitric oxide-donating prostaglandin F2α analog. It is metabolized to latanoprost acid, which is a potent agonist of the prostanoid FP receptor, and butanediol mononitrate, which releases nitric oxide. The dual mechanism of action leads to increased outflow of aqueous humor through both the uveoscleral pathway (mediated by latanoprost acid) and the trabecular meshwork (mediated by nitric oxide).

Clinical Use

Latanoprostene bunod is used for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is administered as an ophthalmic solution.

Side Effects

Common side effects of latanoprostene bunod include eye redness, eye irritation, eye pain, and changes in eye color.

Related Terms

• Glaucoma
• Prodrug
• Latanoprost
• Nitric oxide
• Prostanoid
• Intraocular pressure
• Ocular hypertension

External links

• Medical encyclopedia article on Latanoprostene bunod
• Wikipedia's article - Latanoprostene bunod

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