Lamins
Lamins (/ˈlæmɪnz/; from the Latin lamina, meaning 'layer') are type V intermediate filament proteins. They are the primary components of the nuclear lamina, a proteinaceous structure on the inner part of the nuclear envelope in animal cells.
Etymology
The term Lamin is derived from the Latin word lamina, which means 'layer'. This is in reference to the lamins' role in forming the nuclear lamina, a layer-like structure.
Structure
Lamins are divided into two types: A-type lamins and B-type lamins. A-type lamins include Lamin A and Lamin C, which are produced by alternative splicing of the LMNA gene. B-type lamins include Lamin B1 and Lamin B2, encoded by the LMNB1 and LMNB2 genes respectively.
Function
Lamins are involved in providing mechanical support to the nucleus and also play a role in gene regulation. They are crucial for cell division, DNA replication, and DNA repair.
Related Terms
- Nuclear lamina: The nuclear lamina is a dense fibrillar network inside the nucleus of a eukaryotic cell. It is composed of intermediate filaments and membrane associated proteins.
- Intermediate filaments: These are cytoskeletal components made of protein, including lamins. They play an important role in cellular structure and integrity.
- Laminopathies: These are a group of rare genetic disorders caused by mutations in genes encoding lamins or lamin-associated proteins.
See Also
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