LPP (gene)

LPP (gene)

The LPP gene, also known as LIM domain containing preferred translocation partner in lipoma, is a gene that is found in humans and other organisms. It is located on the third chromosome (3q28-q29) and is known to play a crucial role in cell adhesion, cell shape, and mobility.

Function

The LPP gene encodes a protein that is a member of the zyxin family. This protein is thought to have a role in cell adhesion and cell migration. It is also involved in the regulation of gene expression. The LPP protein interacts with several other proteins, including vinculin, zyxin, and alpha-actinin, which are all involved in the organization of the actin cytoskeleton.

Clinical significance

Mutations in the LPP gene have been associated with a variety of diseases. For example, translocations involving this gene and the HMGA2 gene on chromosome 12 have been observed in lipomas, a type of benign fatty tumor. Additionally, the LPP gene has been implicated in the development of certain types of cancer, including lung cancer and ovarian cancer.

Research

Research into the LPP gene and its associated protein is ongoing. Scientists are particularly interested in understanding how mutations in this gene contribute to the development of cancer and other diseases. This research could potentially lead to the development of new treatments for these conditions.

See also

• LIM domain
• Zyxin
• Vinculin
• Alpha-actinin
• Actin cytoskeleton
• HMGA2
• Lipoma
• Lung cancer
• Ovarian cancer

References

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