KIF23

Overview

Illustration of Kinesin-6 and Kinesin-12

KIF23 is a member of the kinesin superfamily of motor proteins, specifically classified under the Kinesin-6 family. Kinesins are essential for intracellular transport and are involved in various cellular processes, including mitosis, meiosis, and cytokinesis. KIF23 plays a critical role in the proper segregation of chromosomes during cell division.

Structure

KIF23 is a large protein that contains a motor domain, which is responsible for its ATPase activity and interaction with microtubules. The protein also has a stalk region and a tail domain, which are involved in cargo binding and dimerization. The motor domain is highly conserved among kinesins, allowing KIF23 to convert chemical energy from ATP hydrolysis into mechanical work.

Function

KIF23 is primarily involved in the process of cytokinesis, the final step of cell division where the cytoplasm of a parental cell is divided into two daughter cells. It is a key component of the central spindle and the midbody, structures that are crucial for the successful completion of cytokinesis. KIF23 interacts with other proteins, such as PRC1 and MKLP1, to ensure the proper formation and function of the central spindle.

Mechanism of Action

Kinesin-6 and Kinesin-12 in action

KIF23 moves along microtubules in a plus-end directed manner, meaning it travels towards the growing end of the microtubule. This movement is powered by the hydrolysis of ATP, which induces conformational changes in the motor domain, allowing it to "walk" along the microtubule. During cytokinesis, KIF23 helps to organize the microtubules of the central spindle and facilitates the ingression of the cleavage furrow.

Clinical Significance

Mutations or dysregulation of KIF23 have been implicated in various diseases, including certain types of cancer. Overexpression of KIF23 has been observed in some tumors, suggesting a role in tumorigenesis. As a result, KIF23 is being studied as a potential target for cancer therapy.

Related pages

• Kinesin
• Cytokinesis
• Microtubule
• Cell division