JWH-398
JWH-398
JWH-398 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds and is used in scientific research to study the endocannabinoid system.
Chemical Properties
JWH-398 is chemically classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical structure includes a naphthalene ring linked to an indole group. The full chemical name is 1-Pentyl-3-(4-chloro-1-naphthoyl)indole.
Pharmacology
JWH-398 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as pain, appetite, and mood.
CB1 Receptor
The CB1 receptor is primarily found in the central nervous system, including the brain. Activation of this receptor by JWH-398 can lead to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the active component of cannabis.
CB2 Receptor
The CB2 receptor is mainly located in the peripheral nervous system and is associated with the immune system. JWH-398's action on the CB2 receptor is thought to modulate inflammation and immune response.
Legal Status
Due to its potential for abuse and lack of medical use, JWH-398 has been classified as a controlled substance in many countries. It is often included in the list of substances banned under synthetic cannabinoid regulations.
Research Applications
JWH-398 is used in research to better understand the endocannabinoid system and the effects of synthetic cannabinoids. Studies often focus on its binding affinity to cannabinoid receptors and its potential therapeutic applications.
Health Effects
The use of JWH-398 can lead to various health effects, including tachycardia, hypertension, and hallucinations. Long-term effects are not well-studied, but concerns exist regarding its impact on mental health and potential for addiction.
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