Irofulven
Irofulven
Irofulven (pronounced: eye-ROH-ful-ven) is a chemotherapeutic agent used in the treatment of various types of cancer. It is a semi-synthetic derivative of illudin, a natural product of the Jack O'Lantern mushroom (Omphalotus olearius).
Etymology
The name "Irofulven" is derived from the chemical structure of the drug, which includes an iron atom (from the Latin "iro") and a fulvene ring (from the Latin "fulvus", meaning yellow).
Mechanism of Action
Irofulven induces cell death by causing DNA damage. It forms covalent adducts with DNA, leading to the formation of DNA cross-links and strand breaks. This disrupts the normal function of DNA and triggers apoptosis, or programmed cell death.
Clinical Use
Irofulven has been studied in clinical trials for the treatment of various types of cancer, including prostate cancer, ovarian cancer, and pancreatic cancer. It is typically used when other treatments have failed.
Side Effects
Common side effects of Irofulven include nausea, vomiting, fatigue, and anemia. More serious side effects can include neutropenia, a condition characterized by low levels of neutrophils, a type of white blood cell.
Related Terms
External links
- Medical encyclopedia article on Irofulven
- Wikipedia's article - Irofulven
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